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Vishal Kumar Sahu

Doktorand · Computational-Biology-Forscher

Computational Drug Discovery, miRNA-Strukturbiologie und Protein-Ligand-Interaktionen — Suche Promotionsstelle in Deutschland

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Vishal Kumar Sahu

Doktorand · Computational Drug Discovery · Bioinformatik

Forschungslabor:Krebs- und Translationales Forschungszentrum

Institution:Dr. D. Y. Patil Institut für Biotechnologie und Bioinformatik, Pune

📍Pune, Maharashtra, Indien

Publikationen

CSIR-NET/JRF

Qualifiziert

GATE

Qualifiziert

Akademische Profile

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§Forschungsinteressen

Kernbereiche des Forschungsschwerpunkts und methodische Expertise

🧬

Computational Drug Discovery

Strukturbasiertes Wirkstoffdesign mittels molekularem Docking (AutoDock Vina), MD-Simulationen (GROMACS) und In-vitro-Validierung — Identifizierung therapeutischer Kandidaten für Krebsziele.

🔬

miRNA- und ncRNA-Strukturbiologie

Dreidimensionale miRNA-Strukturanalyse, Datenbankentwicklung (miRVim) und funktionale Charakterisierung nicht-kodierender RNAs in der Krebsregulation.

⚗️

Protein-Ligand-Interaktionen & MD-Simulationen

Molekulardynamik-Simulationen von Protein-Ligand- und Protein-Membran-Systemen, Bindungsenergie-Berechnungen und Transmembranprotein-Charakterisierung.

📊

Bioinformatik-Pipeline-Entwicklung

Entwicklung automatisierter Rechenpipelines (SieveAI, ExoLoger) für Wirkstoff-Screening, miRNA-Vorhersage und Genomik-Datenmining aus öffentlichen Datenbanken.

🎯

Krebsbiologie & Pharmakologie

In-vitro- und In-silico-Studien zu Krebszielen — zellbasierte Assays (MTT, Koloniebildung, Apoptose), Wirkstoff-Synergie-Analyse und PPAR-Rezeptor-Modulation.

§Publikationen & Forschungsoutput

Begutachtete Artikel, Rezensionen und wissenschaftliche Beiträge — 11 wissenschaftliche Arbeiten

Google-Scholar-Profil ORCID

[1]

Synergistic combination of ritonavir and cisplatin as an efficacious therapy in human cervical cancer cells: a computational drug discovery and in vitro insight

Vishal Kumar Sahu, Pratima Chaudhary, Durgesh K. Nishad, Poonam Kakkar, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2022 · DOI: 10.1080/07391102.2022.2097312

Investigated synergistic drug combination of ritonavir and cisplatin for cervical cancer through computational docking and in vitro validation, demonstrating enhanced therapeutic efficacy.

PubMed Abstract

[2]

Identification of novel PPAR-β/δ agonists from Kaempferol, Quercetin, and Resveratrol derivatives by targeting cancer: An integrative molecular docking and dynamics simulation approach

Vishal Kumar Sahu, Ankit S. Chaudhary

Current Drug Targets, 2022 · DOI: 10.2174/1570180820666221214152939

Identified novel PPAR-β/δ agonists from natural flavonoid derivatives using molecular docking and MD simulations, proposing therapeutic candidates for cancer targeting.

Abstract

[3]

miRVim: Three-dimensional miRNA Structure Database

Vishal Kumar Sahu, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2023 · DOI: 10.2174/0122115366307988240809045125

Developed miRVim, a comprehensive database of three-dimensional miRNA structures sourced from miRBase, PDB, and homology modeling, enabling structural analysis of miRNA–target interactions.

Preprint PubMed Abstract

[4]

Use of In-Silico Tools for Screening a Suitable Phospholipid for Complexation with Lapatinib

Vishal Kumar Sahu, Ankit S. Chaudhary

SSRN Preprint, 2023 · DOI: 10.2139/ssrn.4614576

Screened phospholipid candidates for complexation with Lapatinib using in-silico docking and MD simulation approaches for enhanced drug delivery.

Preprint

[5]

Role of the transmembrane polar residues on CD151 in cholesterol binding

Vishal Kumar Sahu, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2024 · DOI: 10.1080/07391102.2024.2446663

Elucidated the role of transmembrane polar residues of CD151 in cholesterol binding through computational modeling and molecular dynamics, contributing to understanding of tetraspanin–lipid interactions.

Abstract

§Ausbildung & Qualifikationen

2020 – Present

PhD — Cancer & Translational Research

Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune

2015

MSc Biotechnology

T M Bhagalpur University, Bhagalpur

2013

BSc Biotechnology

CSJM University, Kanpur

2010

Intermediate (Class XII)

JNV, Kanpur Nagar

Nationale Prüfungen

CSIR-UGC NET/JRF Life Sciences (JRF & SRF) (2019)GATE Life Sciences (2019)TIFR (2013 and 2019)JNUCEEB (2013 and 2014)