పీహెచ్‌డి పండితుడు

విశాల్ కుమార్ సాహు

పీహెచ్‌డి పండితుడు & పరిశోధకుడు

Computational drug discovery, miRNA structural biology, and protein–ligand interactions

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విశాల్ కుమార్ సాహు

క్యాన్సర్ & ట్రాన్స్‌లేషనల్ రీసెర్చ్‌లో పీహెచ్‌డీ స్కాలర్ | కంప్యూటేషనల్ డ్రగ్ డిస్కవరీ | ఫుల్-స్టాక్ డెవలపర్

పరిశోధన ప్రయోగశాల:క్యాన్సర్ మరియు ట్రాన్స్లేషనల్ రీసెర్చ్ సెంటర్

సంస్థ:డా. డి. వై. పాటీల్ బయోటెక్నాలజీ అండ్ బయోఇన్ఫార్మాటిక్స్ ఇన్స్టిట్యూట్, పూణే

📍పూణే, మహారాష్ట్ర, భారతదేశం

Publications

CSIR-NET/JRF

Qualified

GATE

Qualified

Academic Profiles

🏛️ORCID 🎓Google Scholar 🔬ResearchGate 📊Sci Profiles 📋Vidwan

Developer Profiles

💻GitHub 💼LinkedIn 📦PyPI 🧑‍💻Stack Overflow

§Research Interests

Core areas of research focus and methodological expertise

🧬

Computational Drug Discovery

Structure-based drug design using molecular docking (AutoDock Vina), MD simulations (GROMACS), and in vitro validation — identifying therapeutic candidates for cancer targets.

🔬

miRNA & ncRNA Structural Biology

Three-dimensional miRNA structure analysis, database development (miRVim), and functional characterization of non-coding RNAs in cancer regulation.

⚗️

Protein–Ligand Interactions & MD Simulations

Molecular dynamics simulations of protein–ligand and protein–membrane systems, binding free energy calculations, and transmembrane protein characterization.

📊

Bioinformatics Pipeline Development

Development of automated computational pipelines (SieveAI, ExoLoger) for drug screening, miRNA prediction, and genomics data mining from public databases.

🎯

Cancer Biology & Pharmacology

In vitro and in silico studies on cancer targets — cell-based assays (MTT, colony formation, apoptosis), drug synergy analysis, and PPAR receptor modulation.

§పరిశోధన అవుట్‌పుట్

అకడమిక్ ప్రచురణలు, సమీక్షలు, మరియు పండితోచిత సహకారాలు — 11 scholarly works

Google Scholar Profile ORCID

[1]

Synergistic combination of ritonavir and cisplatin as an efficacious therapy in human cervical cancer cells: a computational drug discovery and in vitro insight

Vishal Kumar Sahu, Pratima Chaudhary, Durgesh K. Nishad, Poonam Kakkar, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2022 · DOI: 10.1080/07391102.2022.2097312

Investigated synergistic drug combination of ritonavir and cisplatin for cervical cancer through computational docking and in vitro validation, demonstrating enhanced therapeutic efficacy.

PubMed Abstract

[2]

Identification of novel PPAR-β/δ agonists from Kaempferol, Quercetin, and Resveratrol derivatives by targeting cancer: An integrative molecular docking and dynamics simulation approach

Vishal Kumar Sahu, Ankit S. Chaudhary

Current Drug Targets, 2022 · DOI: 10.2174/1570180820666221214152939

Identified novel PPAR-β/δ agonists from natural flavonoid derivatives using molecular docking and MD simulations, proposing therapeutic candidates for cancer targeting.

Abstract

[3]

miRVim: Three-dimensional miRNA Structure Database

Vishal Kumar Sahu, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2023 · DOI: 10.2174/0122115366307988240809045125

Developed miRVim, a comprehensive database of three-dimensional miRNA structures sourced from miRBase, PDB, and homology modeling, enabling structural analysis of miRNA–target interactions.

Preprint PubMed Abstract

[4]

Use of In-Silico Tools for Screening a Suitable Phospholipid for Complexation with Lapatinib

Vishal Kumar Sahu, Ankit S. Chaudhary

SSRN Preprint, 2023 · DOI: 10.2139/ssrn.4614576

Screened phospholipid candidates for complexation with Lapatinib using in-silico docking and MD simulation approaches for enhanced drug delivery.

Preprint

[5]

Role of the transmembrane polar residues on CD151 in cholesterol binding

Vishal Kumar Sahu, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2024 · DOI: 10.1080/07391102.2024.2446663

Elucidated the role of transmembrane polar residues of CD151 in cholesterol binding through computational modeling and molecular dynamics, contributing to understanding of tetraspanin–lipid interactions.

Abstract

§విద్య

2020 – Present

PhD — Cancer & Translational Research

Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune

2015

MSc Biotechnology

T M Bhagalpur University, Bhagalpur

2013

BSc Biotechnology

CSJM University, Kanpur

2010

Intermediate (Class XII)

JNV, Kanpur Nagar

జాతీయ స్థాయి పరీక్షలు

CSIR-UGC NET/JRF Life Sciences (JRF & SRF) (2019)GATE Life Sciences (2019)TIFR (2013 and 2019)JNUCEEB (2013 and 2014)