ಪಿಎಚ್‌ಡಿ ವಿದ್ವಾಂಸ

ವಿಶಾಲ್ ಕುಮಾರ್ ಸಾಹು

ಪಿಎಚ್‌ಡಿ ವಿದ್ವಾಂಸ & ಸಂಶೋಧಕ

Computational drug discovery, miRNA structural biology, and protein–ligand interactions

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ವಿಶಾಲ್ ಕುಮಾರ್ ಸಾಹು

ಕ್ಯಾನ್ಸರ್ ಮತ್ತು ಟ್ರಾನ್ಸ್ಲೇಷನಲ್ ರಿಸರ್ಚ್‌ನಲ್ಲಿ ಪಿಎಚ್‌ಡಿ ಸ್ಕಾಲರ್ | ಕಂಪ್ಯೂಟೇಷನಲ್ ಡ್ರಗ್ ಡಿಸ್ಕವರಿ | ಫುಲ್-ಸ್ಟಾಕ್ ಡೆವಲಪರ್

ಸಂಶೋಧನಾ ಪ್ರಯೋಗಶಾಲೆ:ಕ್ಯಾನ್ಸರ್ ಮತ್ತು ಟ್ರಾನ್ಸ್ಲೇಷನಲ್ ರಿಸರ್ಚ್ ಸೆಂಟರ್

ಸಂಸ್ಥೆ:ಡಾ. ಡಿ. ವೈ. ಪಾಟೀಲ್ ಬಯೋಟೆಕ್ನಾಲಜಿ ಅಂಡ್ ಬಯೋಇನ್ಫಾರ್ಮಾಟಿಕ್ಸ್ ಇನ್ಸ್ಟಿಟ್ಯೂಟ್, ಪುಣೆ

📍ಪುಣೆ, ಮಹಾರಾಷ್ಟ್ರ, ಭಾರತ

Publications

CSIR-NET/JRF

Qualified

GATE

Qualified

Academic Profiles

🏛️ORCID 🎓Google Scholar 🔬ResearchGate 📊Sci Profiles 📋Vidwan

Developer Profiles

💻GitHub 💼LinkedIn 📦PyPI 🧑‍💻Stack Overflow

§Research Interests

Core areas of research focus and methodological expertise

🧬

Computational Drug Discovery

Structure-based drug design using molecular docking (AutoDock Vina), MD simulations (GROMACS), and in vitro validation — identifying therapeutic candidates for cancer targets.

🔬

miRNA & ncRNA Structural Biology

Three-dimensional miRNA structure analysis, database development (miRVim), and functional characterization of non-coding RNAs in cancer regulation.

⚗️

Protein–Ligand Interactions & MD Simulations

Molecular dynamics simulations of protein–ligand and protein–membrane systems, binding free energy calculations, and transmembrane protein characterization.

📊

Bioinformatics Pipeline Development

Development of automated computational pipelines (SieveAI, ExoLoger) for drug screening, miRNA prediction, and genomics data mining from public databases.

🎯

Cancer Biology & Pharmacology

In vitro and in silico studies on cancer targets — cell-based assays (MTT, colony formation, apoptosis), drug synergy analysis, and PPAR receptor modulation.

§ಸಂಶೋಧನಾ ಔಟ್‌ಪುಟ್

ಶೈಕ್ಷಣಿಕ ಪ್ರಕಟಣೆಗಳು, ವಿಮರ್ಶೆಗಳು, ಮತ್ತು ವಿದ್ವದೊತ್ತಿಗೆಗಳು — 11 scholarly works

Google Scholar Profile ORCID

[1]

Synergistic combination of ritonavir and cisplatin as an efficacious therapy in human cervical cancer cells: a computational drug discovery and in vitro insight

Vishal Kumar Sahu, Pratima Chaudhary, Durgesh K. Nishad, Poonam Kakkar, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2022 · DOI: 10.1080/07391102.2022.2097312

Investigated synergistic drug combination of ritonavir and cisplatin for cervical cancer through computational docking and in vitro validation, demonstrating enhanced therapeutic efficacy.

PubMed Abstract

[2]

Identification of novel PPAR-β/δ agonists from Kaempferol, Quercetin, and Resveratrol derivatives by targeting cancer: An integrative molecular docking and dynamics simulation approach

Vishal Kumar Sahu, Ankit S. Chaudhary

Current Drug Targets, 2022 · DOI: 10.2174/1570180820666221214152939

Identified novel PPAR-β/δ agonists from natural flavonoid derivatives using molecular docking and MD simulations, proposing therapeutic candidates for cancer targeting.

Abstract

[3]

miRVim: Three-dimensional miRNA Structure Database

Vishal Kumar Sahu, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2023 · DOI: 10.2174/0122115366307988240809045125

Developed miRVim, a comprehensive database of three-dimensional miRNA structures sourced from miRBase, PDB, and homology modeling, enabling structural analysis of miRNA–target interactions.

Preprint PubMed Abstract

[4]

Use of In-Silico Tools for Screening a Suitable Phospholipid for Complexation with Lapatinib

Vishal Kumar Sahu, Ankit S. Chaudhary

SSRN Preprint, 2023 · DOI: 10.2139/ssrn.4614576

Screened phospholipid candidates for complexation with Lapatinib using in-silico docking and MD simulation approaches for enhanced drug delivery.

Preprint

[5]

Role of the transmembrane polar residues on CD151 in cholesterol binding

Vishal Kumar Sahu, Ankit S. Chaudhary

Journal of Biomolecular Structure and Dynamics, 2024 · DOI: 10.1080/07391102.2024.2446663

Elucidated the role of transmembrane polar residues of CD151 in cholesterol binding through computational modeling and molecular dynamics, contributing to understanding of tetraspanin–lipid interactions.

Abstract

§ಶಿಕ್ಷಣ

2020 – Present

PhD — Cancer & Translational Research

Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune

2015

MSc Biotechnology

T M Bhagalpur University, Bhagalpur

2013

BSc Biotechnology

CSJM University, Kanpur

2010

Intermediate (Class XII)

JNV, Kanpur Nagar

ರಾಷ್ಟ್ರೀಯ ಮಟ್ಟದ ಪರೀಕ್ಷೆಗಳು

CSIR-UGC NET/JRF Life Sciences (JRF & SRF) (2019)GATE Life Sciences (2019)TIFR (2013 and 2019)JNUCEEB (2013 and 2014)